Glycomics is a field of studies about the glycom chain (Glycom), which can be used for developing new medicines or various studies by manipulating the molecules of the sugar by studying the activity of sugar. In general, the protein that functions in the human body becomes sugar or falls, and the actual function is activated and inactivated. NFML analyzes and identifies disease markers as diagnostic and prognostic markers for specific diseases through glycolysis of several animals and humans.

Research highlight

  • Establishment of analytical method for extraction and enrichment of glycoconjugates from biological samples
  • Multi-level glycomics characterization from intact protein to native glycan
  • Discovery novel specific biomarkers of diseases
  • Statistical analysis of samples with various characteristics and conditions

Relevant publications

  • Seo, N., Ko, J., Lee, D., Jeong, H., Oh, M. J., Kim, U., ... & An, H. J. In-depth characterization of non-human sialic acid (Neu5Gc) in human serum using label-free ZIC-HILIC/MRM-MS. Analytical and Bioanalytical Chemistry 2021, 413, 5227-5237.
  • Seo, N., Lee, H., Oh, M. J., Kim, G. H., Lee, S. G., Ahn, J. K., ... & An, H. J. Isomer-Specific Monitoring of Sialylated N-Glycans Reveals Association of α2,3-Linked Sialic Acid Epitope with Behcet’s Disease. Frontiers in Molecular Biosciences 2021, 1120.
  • Lee, J., Ha, S., Kim, M., Kim, S. W., Yun, J., Ozcan, S., ... & An, H. J. Spatial and temporal diversity of glycome expression in mammalian brain. Proceedings of the National Academy of Sciences, 2020, 117.46: 28743-28753.
  • Lee H, Lee A, Seo N, Oh J, Kweon OK, An HJ, Kim J. Discovery of N-glycan Biomarkers for the Canine Osteoarthritis. Life (Basel) 2020, 10(9).
  • Lee SH, Jeong S, Lee J, Yeo IS, Oh MJ, Kim U, Kim S, Kim SH, Park S-Y, Kim J-H et al: Glycomic profiling of targeted serum haptoglobin for gastric cancer using nano LC/MS and LC/MS/MS. Mol Biosyst 2016, 12(12):3611-3621
  • Kim, J.-H., Park, C. W., Um, D., Baek, K. H., Jo, Y., An, H., Kim, T. J. 2014. Mass Spectrometric Screening of Ovarian Cancer with Serum Glycans. Disease Markers, pp. 1–9.